ea0042oc10 | (1) | Androgens2016
Munkley Jennifer
, Livermore Karen E.
, Vodak Daniel
, James Katherine
, Wilson Brian T.
, McClurg Urszula L.
, Knight Bridget
, MCcullagh Paul
, Mcgrath John
, Crundwell Malcolm
, Harries Lorna W.
, Leung Hing Y.
, Robson Craig N.
, Oltean Sebastian
, Mills Ian G.
, Rajan Prabhakar
, Elliott David J.
Changes in glycan composition are common in cancer and can play important roles in all of the recognised hallmarks of cancer (1). We recently identified glycosylation as a global target for androgen control in prostate cancer cells and further defined a set of 8 glycosylation enzymes (GALNT7, ST6GalNAc1, GCNT1, UAP1, PGM3, CSGALNACT1, ST6GAL1 and EDEM3), which are also significantly up-regulated in prostate cancer tissue (4). These 8 enzymes are under direct control of the and...